The anorectic gut hormones GLP-1 (glucagon-like peptide 1) and co-secreted peptides such as oxyntomodulin and PYY are among prime candidates for manipulation in the development of new therapies for obesity. Here their secretion and actions in pathways regulating food intake are briefly outlined.

GLP-1 analogs for the treatment of type-2 diabetes

GLP-1 is an important peptide hormone which is released from the intestine when we eat. It stimulates the secretion of insulin from the pancreas and helps to ensure that enough insulin is released to match the amount and composition of the food that is eaten.